Effect of mild hypothermia on early neurological deterioration after main artery occlusive stroke with intra-arterial thrombolysis
10.3969/j.issn.1006-5725.2014.15.020
- VernacularTitle:亚低温对大动脉闭塞性脑卒中动脉溶栓后早期神经功能恶化的影响
- Author:
Guoshuai YANG
;
Xiaoyan ZHOU
;
Zhiping ZHOU
;
Dan YU
- Publication Type:Journal Article
- Keywords:
Stroke;
Mild hypothermia;
Intra-arterial thrombolysis;
Early neurological deterioration
- From:
The Journal of Practical Medicine
2014;(15):2414-2416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore effects of mild hypothermia on early neurological deterioration (END) after main arterial occlusive with intra-arterial thrombolysis. Methods Fifty patients were randomly divided into mild hypothermia and conventional group, to compared the changes of ICP, CVP, MAP, Blood K+, PT, PLT, ScvO2 and NIHSS before- treatment and 24 h and 7 d after- treatment , prognosis and mortality were evaluated by MRS after 90 d. Results (1) Compared with pre-treatment, 7 d NIHSS of mild hypothermia group decreased (P < 0.01); 24 h, 7 d ICP and ScvO2 improved significantly (P < 0.05); 24 h decreased significantly (P <0.05), while 7 d blood K+ showed no differences. (2) Compared with conventional group, mild hypothermia group 7 d NIHSS and 24 h, 7 d ICP and ScvO2 improved significantly (P < 0.05). (3) The CVP, MAP, PT, and PLT showed no difference in two groups before and after-treatment . ( 4 ) Rate of good outcome in mild hypothermia group was significantly higher than conventional group in 90 days (P < 0.01); while the mortality rate showed no difference. Conclusions Mild hypothermia can obviously improve END in stroke with intra-arterial thrombolysise, bring better outcome among survival patients, though can not reduce mortality.