Expression of programmed cell death 5 in endometrial adenocarcinoma and its clinical significance

VernacularTitle:程序性细胞死亡因子5在子宫内膜癌组织中的表达及意义
Author: Shumin LIU ; Yingzi ZHANG ; Tianhe XU
Publication Type:Journal Article
Keywords: Endometrial neoplasms; Real-time PCR; Immunohistochemistry; Programmed cell death 5
From: Chinese Journal of Primary Medicine and Pharmacy 2014;(19):2907-2909
CountryChina
Language:Chinese
Abstract: Objective This study was designed to investigate the relationship between programmed cell death 5 (PDCD5) and endometrial carcinoma .Methods 60 tissue samples of endometrial carcinomas ,40 normal proliferative endometrium tissues and 28 endometrial atypical hyperplasia tissues were obtained from patients who underwent operation.The expression of PDCD5 was detected by Real-time PCR and immunohistochemical analysis . Results In normal proliferative endometrium , atypical hyperplasia tissues and endometrial carcinoma , the PDCD5 mRNA was gradually decreased[(1.21 ±0.16),(0.83 ±0.07),(0.42 ±0.02),F=5.637,P<0.05];The posi-tive rate of protein was gradually decreased (82.5%,64.3%,45.0%,χ2 =27.663,P<0.05);The expression of PDCD5 was correlated with TNM stage , histological grade , depth of myometrial invasion and lymphatic metastasis (χ2 =20.875,11.915,9.409,11.148,all P<0.05),but was not correlated with ages (χ2 =0.287,P>0.05). Conclusion PDCD5 might become a potential molecular marker of early diagnosis of endometrial carcinoma .