Pseudokinases secreted by rhoptry in Toxoplasma gondii
10.3969/cjz.j.issn.1002-2694.2014.08.016
- VernacularTitle:弓形虫棒状体分泌毒性因子-假激酶的研究进展
- Author:
Guihua ZHAO
;
Wandong HAO
;
Kun YIN
- Publication Type:Journal Article
- Keywords:
Toxoplasma gondii;
rhoptry secretory virulence factors;
pseudokinases;
structure;
function
- From:
Chinese Journal of Zoonoses
2014;(8):855-859
- CountryChina
- Language:Chinese
-
Abstract:
Toxoplasma gondii rhoptry proteins (ROPs) include dozens of proteins secreted by tachyzoites ,these ROPs are known to be critical for several processes such as invasion ,parasitophorous vacuole establishment ,proliferation ,egress and getting out of host immune protection .ROPs belong to the protein kinase family and have classic kinase domain ,however ,most of the members are designated as pseudokinases due to the lack of critical catalytic residues that are normally required for phos-phorylation of host signal molecules .Recent studies indicated that pseudokinases also have important functions ,such as regula-ting kinase activity by allosteric and promoting the interactions between proteins as scaffolds .In this paper ,we summarize the pseudokinases structural characteristics and some pseudokinases functions ,for the study of toxop lasma gondii and host interac-tion mechanisms ,molecular vaccines screening and drugs design .
