Application of MALDI-TOF MS in clinical microbiology identification
10.3969/cjz.j.issn.1002-2694.2014.08.018
- VernacularTitle:基质辅助激光解吸电离飞行时间质谱在临床微生物鉴定中的应用
- Author:
Haoyun LIN
;
Wenyuan WU
- Publication Type:Journal Article
- Keywords:
MALDI-TOF MS;
mass spectrometry;
microbiology identification
- From:
Chinese Journal of Zoonoses
2014;(8):866-870
- CountryChina
- Language:Chinese
-
Abstract:
In recent years ,matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) is a new organic soft ionization mass spectrometry which can identify and classify microorganism by directly using the sam-ple itself or cultivate colonies on petri dish in a few minutes .This new and simple method reduces the cost of consumables and the time of diagnosis greatly .Its reliability and accuracy have been shown in many studies and different system devices have al-ready been on the market .In the near future ,MALDI-TOF MS will have a broader prospect .This mass spectrometry will be-come an effective and fast microbial identification technology to replace the conventional method .In this article ,we will review the principles of MALDI-TOF MS ,its development and application ,its advantages and shortcomings which compared with tra-ditional methods at the present stage ,and the emphasis will focus on the application characteristics of MALDI-TOF MS in mi-crobial systems .
