The study of diffusion tensor imaging in patients with mild cognitive impairment
10.3969/j.issn.1002-1671.2014.08.002
- VernacularTitle:轻度认知障碍的 MR 扩散张量成像研究
- Author:
Li HE
;
Zhai LIU
;
Qingyun REN
;
Licun LEI
;
Yuxuan QI
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
diffusion tensor imaging;
mild cognitive impairment;
white matter
- From:
Journal of Practical Radiology
2014;(8):1255-1258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of diffusion tensor imaging (DTI)in diagnosing MCI.Methods DTI and conventional MRI were performed in 26 patients with MCI and 26 age-matched normal control subjects (NC).FA were measured in the 10 select-ed white matter regions,included bilateral frontal lobe,temporal lobe,parietal lobe,parahippocampal gyrus and cingulate gyrus,in the patients with MCI (n=26)and NC (n=26).FA of each ROI (region of interest)between the patients and controls were com-pared by using independent sample t-test.The correlation between the FA values and the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)scores was analyzed by using Spearman correlation analysis.Results Compared with NC,the FA values of the right frontal lobe,temporal lobe white matter and bilateral cingulate gyrus in the patients were significant-ly reduced (P <0.05).FA values of the left temporal lobe,right frontal lobe and bilateral parahippocampal gyrus were significant correlated with MoCA scores,and FA values of the bilateral parahippocampal gyrus were significant correlated with MMSE scores (P <0.05).Conclusion DTI can be used as a diagnosis index of MCI.It has important value in early intervention and improving the quality of life of patients to early diagnosing MCI.
