Meta analysis on the levels of total Tau protein and β-amyloid42 in cerebrospinal fluid in mild cognitive impairment patients
10.3936/j.issn.1002-0152.2014.06.005
- VernacularTitle:轻度认知障碍患者脑脊液总Tau蛋白与β42淀粉样蛋白的Meta分析
- Author:
Yuan ZHENG
;
Zhongmin WEN
- Publication Type:Journal Article
- Keywords:
Mild cognitive impairment (MCI);
Meta-analysis;
Tau protein;
β-amyloid
- From:
Chinese Journal of Nervous and Mental Diseases
2014;(6):341-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the changes of the level of cerebrospinal fluid T-tau protein andβ-amyloid 42 in mild cognitive impairment (MCI) patients. Methods Computer retrieval was preformed for cerebrospinal fluid (CSF) to-tal tau protein (T-tau) and β-amyloid 42 (Aβ 42) levels among MCI and healthy people in Pubmed, Cochrane Library, Ovid, CNKI, VIP Data and Wangfang Data. Meta-analyses were conducted on the T-tau and Aβ42 levels using Review Manager 5.2 software. Results Seventeen studies met inclusion criteria. Meta-analysis results showed that, CSF T-tau protein levels were significantly higher (MD:113.10;95%CI:87.93-138.26) and Aβ42 levels were significantly lower in the patients with MCI, (MD=-146.50;95%CI=-178.70- -114.29) compared with the control group (P<0.01). Conclu-sions T-tau significantly increases while Aβ42 significantly decreases in the CSF in patients with MCI.
