Progress in neural-plasticity mechanisms of faster-onset antidepressants
10.3867/j.issn.1000-3002.2014.04.017
- VernacularTitle:快速起效抗抑郁药的神经可塑性机制研究进展
- Author:
Linghong CHEN
;
Zhongze LOU
;
Wenhua ZHOU
- Publication Type:Journal Article
- Keywords:
depression;
neuraI pIasticity;
brain-derived neurotrophic factor;
ketamine;
scopoIamine
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):580-586
- CountryChina
- Language:Chinese
-
Abstract:
Basic and cIinicaI studies demonstrate that depression is associated with abnormaI neuraI pIasticity in some brain regions,incIuding the prefrontaI cortex and hippocampus. Brain-derived neurotro-phic factor(BDNF)and its signaIing pathways pIay a cruciaI roIe in reguIating neuraI pIasticity and deveI-opment of depression. Ketamine or scopoIamine can produce a quick and sustained antidepressant effect,and both can quictIy activate BDNF-signaIing pathways reIated to neuraI pIasticity. In order to pro-vide the theoreticaI basis for future researches on new antidepressants,the neuraI pIasticity mechanisms of faster-onset antidepressants are reviewed in this paper.
