Progress in radiosensitization of hypoxia-inducible factor-1 inhibitors
10.3867/j.issn.1000-3002.2014.04.020
- VernacularTitle:缺氧诱导因子-1抑制剂放射增敏作用的研究进展
- Author:
Hinfa CAO
;
Hong LIU
;
Mengjiao SONG
- Publication Type:Journal Article
- Keywords:
hypoxia-inducibIe factor-1;
radiosensitizer;
hypoxia ceIIs;
tumor
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):600-605
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducibIe factor-1(HIF-1)is a main nucIear transcription factor for response to intratumor hypoxia. RecentIy,it has become a hot spot to attempt to improve hypoxia by inhibiting HIF-1. HIF-1 inhibitors' mechanisms of action are wide,which infIuences the two signaI transduction pathways that are phosphatidyIinositoI-3-kinase/ protein kinase B/ mammaIian target of rapamycin and Ras/ Raf/ mitogen-activated protein kinase kinase1-2/ extraceIIuIar signaI-reguIated kinase1-2,inhibits the function of heat shock protein 90,and reduces transcriptionaI activity of HIF-1. In combination with radiation,HIF-1 inhibi-tors significantIy enhance radiosensitivity and weaken radioresistance of hypoxia ceIIs,which contributes to the therapeutic effect of tumor irradiation.
