Progress in role of breast cancer susceptibility gene 1 in DNA damage repair
10.3867/j.issn.1000-3002.2014.04.021
- VernacularTitle:乳腺癌易感基因1在 DNA 损伤修复中作用的研究进展
- Author:
Xipeng ZHAO
;
Fengmei ZHANG
;
Zhihui FENG
- Publication Type:Journal Article
- Keywords:
breast cancer susceptibiIity gene1;
DNA damage;
DNA repair;
DNA breaks,doubIe-strand;
recombination,genetic
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):606-611
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer susceptibiIity gene 1( BRCA1)is a tumor suppressor,but mutated get BRCA1 is cIoseIy reIated to the deveIopment of breast cancer. Current study has reveaIed that BRCA1 can get invoIved in the DNA damage repair process as a key mediator. DNA doubIe-stranded break (DSB)is the most serious form in DNA Iesions,and BRCA1 pIays an important roIe in repairing DSB through reguIation of homoIogous recombination( HR). In this articIe,the moIecuIar mechanism of BRCA1 in reguIating HR is reviewed with reference to the activity of functionaI domains in BRCA1 struc-ture,the mutations occurring in main domains of BRCA1,the reIationship of BRCA1 with BRCA2, Rad51 or CtIP,and phosphoryIation of BRCA1. In addition,the association of the defective BRCA1-mediated HR repair mechanism with the sensitivity to different DNA damaging agents and synthetic IethaIity in tumor ceIIs is aIso addressed.
