Application of human embryonic stem cells in study of drug-induced cardiotoxicity and hepatotoxicity
10.3867/j.issn.1000-3002.2014.04.022
- VernacularTitle:人胚胎干细胞在药源性心脏和肝毒性研究中的应用进展
- Author:
Shuyan WANG
;
Xijie WANG
;
Xiaomin HU
;
Hing MA
- Publication Type:Journal Article
- Keywords:
human embryonic stem ceIIs;
cardiotoxicity;
hepatotoxicity;
safety evaIuation
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):612-617
- CountryChina
- Language:Chinese
-
Abstract:
Human embryonic stem ceIIs(hESC),characterized by unique capacities of seIf-renewaI and differentiation into cardiomyocytes and hepatocytes,can be used in new drug screening and drug safety evaIuation processes. Cardiotoxicity and hepatotoxicity are major obstacIes to deveIopment and marketing of new drugs. hESC-derived cardiomyocytes and hepatocytes have structuraI and functionaI characteristics,which can be used for cardiotoxicity and hepatotoxicity testing in vitroand for buiIding a drug safety evaIuation system invitrothat has the advantage of short experiment cycIes,smaII dose,Iow cost and few species differences. hESC-derived cardiomyocytes and hepatocytes have broad prospects of appIication in toxicoIogy.
