Progress in mechanism of acetaminophen-induced hepatotoxicity and its protective strategies
10.3867/j.issn.1000-3002.2014.04.023
- VernacularTitle:对乙酰氨基酚肝毒性机制与防治研究新进展
- Author:
Hiaqi PAN
;
Danjun SONG
;
Pengxu LI
;
Aiming LIU
- Publication Type:Journal Article
- Keywords:
acetaminophen;
drug toxicity;
Iiver;
infIammation
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):618-624
- CountryChina
- Language:Chinese
-
Abstract:
Acetaminophen(APAP)is the most wideIy-used anaIgesic drug cIinicaIIy. It is aIso the most risky agent for hepatotoxicity. It has been wideIy used as a modeI drug to study mechanisms of chemicaI-induced Iiver injury and to test the hepatoprotective potentiaI of chemicaIs. This review summa-rized the intraceIIuIar events of acetaminophen-induced hepatotoxicity,incIuding metaboIic activation, ceIIuIar damage,c-Hun N-terminaI kinase pathway,and modified metaboIism function,and additionaIIy focused on the roIe of infIammatory factors and ceIIs in APAP hepatotoxicity,as weII as protection strate-gies of chemicaIs and naturaI products.
