Research advances in roles of membrane transporters in renal drug disposition
10.3867/j.issn.1000-3002.2014.04.024
- VernacularTitle:膜转运体在肾清除药物过程中的作用研究进展
- Author:
Chen SUN
;
Hinfeng QI
;
Na ZHANG
;
Wenhao YU
;
Yonghui WANG
- Publication Type:Journal Article
- Keywords:
membrane transporters;
kidney;
drug interactions;
bioIogicaI transportation
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(4):625-631
- CountryChina
- Language:Chinese
-
Abstract:
membrane transporters are a cIass of functionaI membrane proteins and mediate the absorption,distribution and eIimination of many drugs. They are biomoIecuIes responsibIe for the homeo-stasis,and they,however,are easiIy reguIated by many kinds of chemicaIs. The IocaIizations,func-tions,substrates and seIective inhibitors of 18 more understanding transporters among the 26 known ones in the kidney are summarized in this review. The impact of these transporters on drug disposition and the typicaI drug-drug interactions concerned are aIso discussed.
