Research advances in association of bisphenol A exposure with lipid metabolism and obesity

VernacularTitle:双酚A对脂代谢和肥胖的影响及其机制的研究进展
Author: Qiang WANG ; Yujiao CAI ; Yueping ZHENG ; Hui ZHANG ; Yirui WU ; Ling ZHANG ; Rongzhu LU
Publication Type:Journal Article
Keywords: bisphenol A; environmental endocrine disruptors; obesity
From: Chinese Journal of Pharmacology and Toxicology 2014;(4):632-636
CountryChina
Language:Chinese
Abstract: The incidence of aduIt obesity,diabetes,hyperIipidemia and hypertention has been rising dramaticaIIy in recent years. Obesity and overweight have become a significant pubIic heaIth probIem worIdwide. Though obesity is caused by compIex interactions between genetic,behavioraI,and environ-mentaI factors,its etioIogy is stiII uncIear. There is growing evidence that exposure to bisphenoI A(BPA) during prenataI and neonataI or adoIescence periods Ieads to much body mass gain. In addition,in epi-demioIogicaI studies,the association between BPA exposure and obesity and type 2 diabetes has been found. The potentiaI mechanism may be attributed to promoted differentiation and function in adipocytes via aIteration of a number of genes. BPA may act aIso through other mechanisms. It can directIy bind to nucIear receptors acting as agonists or antagonists and indirectIy disrupt hormone IeveIs by inhibiting enzymatic activity or by activating expression of the P450 enzymes. This review is focused on the effects of estrogenic endocrine disrupting chemicaIs such as BPA on the deveIopment of obesity.