Discussion of vancomycin dosage in Chinese adult patients
- VernacularTitle:中国成人万古霉素给药剂量的商榷
- Author:
Jie FANG
;
Le HE
;
Qijian CHENG
- Publication Type:Journal Article
- Keywords:
vancomycin;
dosage;
serum trough concentration
- From:
Chinese Journal of Infection and Chemotherapy
2014;(4):291-294
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study whether vancomycin dosage 2 g daily in Chinese adult patients would achieve the target serum trough concentration of 10-20 mg/L.Methods The data of 122 adult inpatients under therapeutic drug monitoring while receiving vancomycin were collected from September 2011 to December 2012.The correlation between vancomycin trough concentration and dosage,age,sex,body weight,concomitant medications were analyzed retrospectively.Results Vancomycin trough concentration was below the target concentration in 62.1% of the included patients.Age is an independent risk factor for attainting target concentration.Serum concentration was below target concentration in 70.0% of the patients below 60 years of age.Serum concentration was above target concentration in 62.5% of the patients above 60 years of age.Conclusions Clinicians and pharmacists should assess the dosage regimen of vancomycin cautiously,and age should be considered especially as an independent risk factor.
