Early evaluation of rabbit model of lumbar vertebra tuberculosis by imaging study

VernacularTitle:影像学对兔腰椎结核模型的早期评价
Author: Xiaochen LIU ; Wenxiao JIA ; Hong WANG ; Yunling WANG ; Jingxu MA ; Xuan ZHOU ; Hao WANG
Publication Type:Journal Article
Keywords: spinal tuberculosis; magnetic resonance imaging; computed tomography; radiography
From: Journal of Practical Radiology 2014;(8):1387-1391
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of X-ray,CT and MRI in diagnosing early spinal tuberculosis by constructing lum-bar vertebra tuberculosis model in New Zealand rabbits.Methods Forty healthy New Zealand rabbits were randomly divided into the infected group (n=30)and the control group (n= 10).All rabbits were performed lumbar vertebra surgery,and then underwent imaging and histopathologic examination at 4,6,8 weeks respectively.Results The sensitivity of X-ray,CT and MRI in detecting tuberculosis lesions were 46.13%,76.3%,and 92.3%,respectively.MRI and CT were better than X-ray for displaying the de-struction range limited in a single vertebra (P <0.05).Combination with routine MRI and diffusion-weighted imaging (DWI)could find the vertebra tuberculosis at the early stage.According to the HE staining,pus cells,epithelioid cells or necrosis were seen in the tissue sections of vertebra and paraspinal soft tissues in the infected group.Conclusion X-ray,CT and MRI could provide some information for the early diagnosis of spinal tuberculosis,and MRI is more sensitive.