The changes in the multiple myeloma diagnostic criteria and its impact on treatment
10.3969/j.issn.1000-8179.20140929
- VernacularTitle:多发性骨髓瘤诊断标准的变迁及其对治疗的影响
- Author:
Jin LU
- Publication Type:Journal Article
- Keywords:
multiple myeloma (MM);
diagnostic criteria;
therapy
- From:
Chinese Journal of Clinical Oncology
2014;(13):819-822
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM) was the second malignant hematological disease in many countries. There had continuing change in diagnostic criteria in MM, along with the more treatment methods and the understand of this disease. From 1975 to 2013, the change of diagnostic criteria experienced three stages. Firstly, we emphasized the numerical value in 1975, secondly, we emphasized the clonal characteristics of plasma cell and wakened the numerical value because of the FACS and immunofixation widespreadly used, thirdly, we emphasized the number again because of the differentiation of primary amyloidosis. Along with these changes, the target population had changed also, 20%patients cannot be diagonsed if using criteria of 1975, and some asymptomatic MM may be diag-nosed with MM in the future.
