Application of Factor Analysis in Imaging Mass Spectrometric Data Analysis

VernacularTitle:因子分析法在质谱成像数据分析中的应用
Author: Yi CHEN ; Fei TANG ; Tiegang LI ; Jiuming HE ; Zeper ABLIZ ; Litao LIU ; Xiaohao WANG
Publication Type:Journal Article
Keywords: Factor analysis; Imaging mass spectrometry; Air flow-assisted ionization; Multiple statistical analysis
From: Chinese Journal of Analytical Chemistry 2014;(8):1099-1103
CountryChina
Language:Chinese
Abstract: The factor analysis method applied in imaging mass spectrometry data analysis was studied. The imaging mass spectrometric data were obtained by air flow-assisted ionization imaging mass spectrometry method. The sample contained some symbols which were drawn on slides using three different inks ( red, blue, black) . The imaging data analyzed by factor analysis method were divided into the background, black, blue and red factor. The results showed that the scores of m/z=443. 2, 478. 4, 322. 2(344. 2) in red, blue, black factor respectively were much larger than others. Therefore, they were markers of three inks. The results accorded with actual condition well and proved that the application of factor analysis in imaging mass spectrometric data analysis was feasible. The data analysis results of factor analysis and principal component analysis were compared. The results showed that the target sample markers could be extracted by factor analysis simply and quantitatively. It was of great potential in biomarker extraction, diseases diagnose and pharmacological analysis.