Determination of Organic Acids from Mainstream Cigarette Smoke using Ultra Low Temperature Solvent Extraction Followed by Comprehensive Two-Dimensional Gas Chromatography/Time-of-Flight Mass Spectrometry
10.11895/j.issn.0253-3820.140253
- VernacularTitle:超低温溶剂提取-全二维气相色谱/飞行时间质谱法测定卷烟主流烟气中有机酸成分
- Author:
Quan ZHANG
;
Zhangmin XIANG
;
Kai CAI
;
Shuping ZHOU
;
Zhaoliang GENG
;
Yushuang GUO
;
Wensheng CHEN
- Publication Type:Journal Article
- Keywords:
Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry;
Ultralow temperature solvent extraction;
Cigarette;
Mainstream smoke;
Organic acids
- From:
Chinese Journal of Analytical Chemistry
2014;(8):1125-1131
- CountryChina
- Language:Chinese
-
Abstract:
A new method for the determination of organic acids from mainstream cigarette smoke using ultra low temperature solvent extraction-comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry(GC×GC-TOF/MS)was established. The mainstream smoke was directly trapped by ethyl ether with ultra low temperature solvent extraction device, and cleaned up with liquid-liquid extraction. The concentrated extracts were further derived by N,O-bis(trimethylsily)trifluoroacetamide (BSTFA). The good separation of silanized product was achieved by the column set of DB-1 (30 m × 0. 25 mm, 1. 0 μm) as the 1st column and DB-wax (1. 5 m × 0. 1 mm, 0. 1 μm) as the 2nd column with modulation period of 6 s and scan range of m/z 45-450 . The results showed that linearity correlation coefficients were larger than 0 . 99 , and the average recoveries were between 80. 17% and 107. 81% with the relative standard deviations (RSD) in the range of 0 . 4%-12 . 1% ( n=5 ) . The detection limit and the quantitation limit were 1 . 3-24 . 5 μg/kg and 4. 1-77. 1 μg/kg, respectively.
