Serum Dectin-1 in non-agranulocytic patients with pulmonary aspergillosis
- VernacularTitle:非粒细胞缺乏肺曲霉病患者血清Dectin-1的检测
- Author:
Xiaoyong XU
;
Fei CHEN
;
Weiwei GAO
;
He SUN
;
Pei LI
;
Yi SHI
- Publication Type:Journal Article
- Keywords:
pulmonary aspergillosis;
non-agranulocytic;
Dectin-1;
immunity
- From:
Chinese Journal of Infection and Chemotherapy
2014;(4):301-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical implication of serum Dectin-1 level in the non-agranulocytic patients with pulmonary aspergillosis. Methods Serum specimen were collected from the non-agranulocytic patients with pulmonary aspergillosis to determine the serum level of Dectin-1 with ELISA.The relationship between serum Dectin-1 level,the results of G test and galactomannan (GM)test of Aspergillus,and white blood cell count was analyzed.Results The serum Dectin-1 level was (427.2 ± 42.6)pg/mL in the patients with Aspergillus infection,and (280.8 ± 39.4)pg/mL in the control patients (P<0.05 ).Dectin-1 level was not correlated to white blood cell count,or the result of G test,or GM test. Conclusions Serum Dectin-1 level increases significantly in the non-agranulocytic patients with pulmonary aspergillosis, suggesting that Dectin-1 is an important anti-Aspergillus immune molecule.
