Application of Planar Microelectrode Array Modified by Nano-structure Titanium Nitride on Dual Mode Neural Information Recording
10.11895/j.issn.0253-3820.140242
- VernacularTitle:纳米TiN修饰平面微电极阵列在神经信息双模检测中的应用
- Author:
Tingjun JIANG
;
Chunxiu LIU
;
Yilin SONG
;
Shengwei XU
;
Wenjing WEI
;
Xinxia CAI
- Publication Type:Journal Article
- Keywords:
Microelectrode array;
Titanium nitride;
Neuroeletrical;
Neurochemical;
Dopamine
- From:
Chinese Journal of Analytical Chemistry
2014;(8):1071-1076
- CountryChina
- Language:Chinese
-
Abstract:
The nano-structure TiN was modified on the laboratory self-made planar microelectrode array pMEA by magnetron sputtering method. The performance of modified pMEA was investigated. Research on neuroelectrical and neurochemical recording was studied in vitro. The impedance of the modified pMEA was decreased almost one order of magnitude, and the background noise level was reduced to ±6 μV. In the same testing environment, the signal-to-noise ratio (SNR) of modified electrodes was 1. 7 times of bare electrodes. The SNR of neuroelectrical recording on the brain slice of SD rats reached 10:1 , and the weak signal such as ±12 μV was separated easily. For neuroelectrical recordings, the detection limit of dopamine ( DA) solution reached 50 nmol/L with the 2:1 (S/N). During the concentration range of 0. 05-100 μmol/L, the linearly correlation coefficient of the DA oxidation currents was 0 . 998 . The modification of nano-structure TiN on pMEA reduced pMEA impedance and background noise level, meanwhile the SNR was increased. The weak signals of neuroelectrical and neurochemical recording were successfully recorded.
