Correlation between interleukin-10 and T regulatory cells in leprosy patients
10.3969/j.issn.1000-484X.2014.08.022
- VernacularTitle:麻风病患者外周血IL-10与调节性T细胞的相关性研究
- Author:
Caixia LI
;
Lin LU
;
Xiaohong ZHOU
;
Zihong ZOU
;
Yuanpin XU
;
Xiaolin WANG
;
Wenli DING
;
Xiaohong ZHANG
;
Xiaolan LI
- Publication Type:Journal Article
- Keywords:
Leprosy;
IL-10;
Treg;
Correlation
- From:
Chinese Journal of Immunology
2014;(8):1105-1107
- CountryChina
- Language:Chinese
-
Abstract:
To detect the correlation between Interleukin-10 and CD4+CD25+Foxp3+regulation T cells ( Treg) and to explore the significance and mechanism of them in leprosy patients.Methods:We used the cytometric bead arra (CBA) to detect the serum Interleukin-10 in 30 leprosy patients and we used flow cytometry to test the Treg cells in 51 leprosy persons.Results:The con-centration of serum IL-10 in leprosy patients(130.00±54.27)pg/ml was higher than normal people(15.64±7.11)pg/ml,(P<0.05);The percentage of Treg cells in leprosy patients(17.626±8.1977)%was higher than normal people(9.998±1.7062)%,(P<0.05).The relevance between IL-10 and Treg is positive and linear ,( P<0.05 ).Conclusion: The imbalance between IL-10 and Treg cells may lead to immune abnormal in leprosy patients.
