Study on Anti-hyperuricemia Effect of Geniposide
10.11842/wst.2014.07.019
- VernacularTitle:栀子苷降尿酸作用研究
- Author:
Zhaoqing MENG
;
Zhaohui TANG
;
Yunxia YAN
;
Gang DING
;
Wei XIAO
;
Zhonglin YANG
- Publication Type:Journal Article
- Keywords:
Geniposide;
hyperuricemia;
uric acid;
urinary uric acid;
hepatic xanthine oxidase activities
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(7):1565-1568
- CountryChina
- Language:Chinese
-
Abstract:
This article was aimed to study the effect of geniposide in hyperuricemia mice. Different doses (50, 100, 200 mg·kg-1) of geniposide were administrated to hyperuricemia mice induced by potassium oxonate by gavage for seven consecutive days. Then, serum uric acid (SUA), urinary uric acid (UUA) and the hepatic xanthine oxidase ac-tivities (XOD) of mice were detected. The results showed that the middle- and high-dose groups of geniposide re-duced the level of SUA significantly (P<0.01). It was concluded that geniposide can reduce the level of SUA in hy-peruricemia mice by promoting UUA excretion.
