Analysis on Plasma Metabolicomics Pathway in Rats with Heart Blood Stasis Syndrome
10.11842/wst.2014.07.029
- VernacularTitle:心血瘀阻证大鼠血浆代谢网络模型分析
- Author:
Jinghui ZHENG
;
Yunqiu MO
;
Weixiong JIAN
;
Guilan NING
;
Yaping ZHANG
;
Zhihua ZHU
;
Zhuo WEI
;
Jing HE
;
Tiehua WANG
- Publication Type:Journal Article
- Keywords:
Metabolicomics;
heart blood stasis syndrome;
metabolic pathway;
pantothenate and CoA biosynthesis;
propanoate metabolism;
biosynthesis of unsaturated fatty acids
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(7):1614-1618
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to analyze the plasma metabolicomics pathway in rats with heart blood stasis syn-drome. KEGG database was used in the signal pathway analysis. HMDB was used in the analysis of molecular metabolite annotation, enzyme or transporter associated and its related properties. The metPA network software was used in the visualization of metabolite path. The results showed that 9 metabolites involved in 15 metabolic pathways. Among them, the P-value of metabolic pathway of pantothenate and CoA biosynthesis, propanoate metabolism, biosynthesis of unsaturated fatty acids was less than 0.05. It was concluded that the metabolic pathways of pan-tothenate and CoA biosynthesis, propanoate metabolism, biosynthesis of unsaturated fatty acids were involved with the pathological process of rats with heart blood stasis syndrome.
