Influence of PIMT on apoptosis of fibroblast-like synoviocytes in rheumatoid ar-thritis
10.3969/j.issn.1000-484X.2014.08.002
- VernacularTitle:PIMT对类风湿关节炎成纤维样滑膜细胞凋亡的影响
- Author:
Hui ZHANG
;
Ming ZONG
;
Niu LI
;
Shanshan YU
;
Lishan SUN
;
Lieying FAN
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Fibroblast-like synoviocytes;
Protein isoaspartyl-methyltransferase;
Cell apoptosis
- From:
Chinese Journal of Immunology
2014;(8):1015-1018
- CountryChina
- Language:Chinese
-
Abstract:
To prove the influence of protein isoaspartyl-methyltransferase ( PIMT ) on the cell apoptosis of fibroblast-like synoviocytes of RA.Methods: The expression vector of PIMT was constructed and transfected in to the RA-FLS, the impact of PIMT on the cell apoptosis of RA-FLS was observed by overexpressing the vector of PIMT.Results:The mRNA and protein level of PIMT in RA-FLS was increased after transfected the vector of PIMT into RA-FLS;compared with the normal cultured RA-FLS and the RA-FLS transfected with the empty vectors ,the cell apoptosis level was also increased.Conclusion:The decreased expression level of PIMT in RA-FLS is an important reason for reduce apoptosis of RA-FLS,and PIMT can affect the imbalance of proliferation/ap-optosis in the RA-FLS.
