Pathological changes in lung tissue during fast floating escape-induced decompression sickness
10.7644/j.issn.1674-9960.2014.07.004
- VernacularTitle:快速上浮脱险致减压病动物肺组织病理改变的研究
- Author:
Pu YOU
;
Yiqun FANG
;
Haitao WANG
;
Xiaochen BAO
;
Shi ZHANG
;
Jun MA
;
Fangfang WANG
- Publication Type:Journal Article
- Keywords:
fast floating escape;
decompression sickness;
pathological score
- From:
Military Medical Sciences
2014;(7):490-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the pathological changes of lung tissues during fast floating escape-induced decompres-sion sickness.Methods Eighty male SD rats were randomly divided into 2 groups, 60 in fast floating escape group (escape group) , and 20 in control group .Rats in the control group were only put in a cabin under the same atmospheric pressure (ATM).Rats in escape group were pressurized to 1.5 MPa by pressure air at the 2t/7 exponential rate and stayed for 4 min till decompression.Then the rats′survival rate was observed after 0.5 h, lung tissue specimens were collected from each rat, the pathological score was taken , according to the degree of lung injury and the R language was used for statistical analysis.Results The mortality rate was 50%.Lung tissues of these rats were pathologically characterized by stromal lung thickening, edema, and hyperemia.Kruskal non-parametric test analysis found a significant difference (P=0.0016) between the two groups .Nemenyi test was used in pairwise comparison .The death and survival animals in escape group compared with the control group, the scores were significantly different (P<0.05).The scores had no significant difference between the deach and survival animal in escape group .Conclusion Decompression sickness caused by fast floating es-cape can significantly damage the blood-lung barrier to cause pulmonary edema .
