Cellular electrophysiologic mechanisms of tachyarrhythmia in rabbits induced by positive acceleration
10.7644/j.issn.1674-9960.2014.07.009
- VernacularTitle:正加速度诱发兔快速性心律失常细胞电生理机制的探讨
- Author:
Lujian DUANMU
;
Lan WANG
;
Yuqian LI
;
Xinya YU
;
Congchun HUANG
;
Junhua WANG
;
Jianchang WANG
- Publication Type:Journal Article
- Keywords:
tachyarrhythmia;
positive acceleration;
transmural dispersion of repolarization;
monophasic action potential
- From:
Military Medical Sciences
2014;(7):506-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of positive acceleration (+Gz) on monophasic action potential duration of 90%repolarization( MAPD90 ) and transmural dispersion of repolarization ( TDR) in ventricles of rabbits and to explore the cellular electrophysiologic mechanism of tachyarrhythmia induced by positive acceleration .Methods Twenty-four healthy, male New Zealand white rabbits were randomly and equally divided into control group and +Gz group.The +Gz group rabbits were given +8 Gz exposure, 1 min a time, 3 times a day,and a total of 7 days.The two groups were subjec-ted to Holter monitoring at the same time to observe the incidence of tachyarrhythmia .Using the monophasic action potential ( MAP) recording technology , the MAP of the left ventricle was recorded while MAPD 90 and TDR were measured .By using Burst stimulation method , the right ventricular anterior wall of the rabbits was stimulated , and the incidence of tachya-rrhythmia was observed .Results The Holter record showed that the incidence of tachyarrhythmias in +Gz group was 55%(6/11), but the control group did not have any case of tachyarrhythmias .Compared with the control group ,MAPD90 of en-docardial and epicardial cells was significantly decreased in the +Gz group, while MAPD90 of middle myocardial cells did not change significantly ,but TDR was increased obviously .Four rabbits in +Gz group suffered from tachyarrhythmias dur-ing Burst stimulation ,and the incidence of tachyarrhythmias was 40% ( 4/10 ) .Conclusion +Gz exposure can increase the incidence of tachyarrhythmias .The shortened MAPD90 of ventricular muscle cells and the increased TDR may be the cell electrophysiological mechanisms of tachyarrhythmias induced by +Gz.
