Study on Intervention of Zi-He-Che on E2, LH, FSH among Perimenopausal Rat Model
10.11842/wst.2014.07.034
- VernacularTitle:紫河车对围绝经期模型大鼠E2、LH、FSH干预作用研究
- Author:
Li ZENG
;
Li ZHANG
;
Yuping LIU
;
Wu JI
;
Yanping CHEN
- Publication Type:Journal Article
- Keywords:
Perimenopause rats;
Zi-He-Che;
estradiol;
follicle stimulating hormone;
luteinizing hormone
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(7):1637-1641
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore effects of Zi-He-Che (ZHC) on estradiol (E2), follicle stimulating hor-mone (FSH), luteinizing hormone (LH) among perimenopausal rat model. The 4-month-old young female SD rats with vaginal smear of normal estrous cycle and 18-month-old aged female SD rats with vaginal smear of no estrous cycle were selected as the normal control group. The 11- and 12-month-old female SD menopausal rats with vaginal smear of estrous cycle disorder were selected and randomly divided into the model group, treatment group and posi-tive control group. The normal control group and the model group were given physiological saline. And the treatment group was given ZHC. The positive control group was given prescription from the textbook. Observation was given on effects of ZHC on E2, LH and FSH among perimenopausal rat model. The results showed that compared with the young group, the level of E2 in the old and model group was significantly decreased (P<0.01), the level of FSH and LH were significantly increased (P<0.01). Compared with the model group, the level of E2 in the treatment group and positive control group was significantly increased (P<0.01), the level of FSH and LH were significantly decreased (P<0.01). It was concluded that both ZHC and prescription from the textbook were able to reduce FSH and LH levels, and increase the estrogen level among perimenopausal rats.
