Study on T-bet/IFN-γ Signal Transduction Pathway in Aplastic Anemia and Chinese Medicine Study Development
10.11842/wst.2014.07.035
- VernacularTitle:再生障碍性贫血T-bet/IFN-γ信号通路及中医研究进展
- Author:
Fengfeng ZHANG
;
Zongjiang ZHAO
;
Xinxue ZHANG
;
Chen TIAN
;
Zhikui WU
- Publication Type:Journal Article
- Keywords:
Aplastic anemia;
immune mechanism;
T-bet/IFN-γ signaling pathways
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(7):1642-1648
- CountryChina
- Language:Chinese
-
Abstract:
Aplastic anemia (AA) is a Tlymphocyte-mediated autoimmune disease. The research on AA was focused on three areas, which were the pathogenesis of immune dysfunction, hematopoietic stem cell damage and abnormal hematopoietic microenvironment. In recent years, more attentions have been paid on abnormal immune mechanisms in the blood. There are complex intracellular cytokine and signal transduction pathway of pathogenesis in AA. And T-bet/IFN-γ signaling pathway plays an important role in development and progression of AA. This article aimed to review T-bet/IFN-γ signaling pathways in AA.
