Expression changes in miR-16 and miR-146a in rat lungs after fast buoyancy ascent escape or diving decompression sickness
10.7644/j.issn.1674-9960.2014.07.002
- VernacularTitle:快速上浮脱险和潜水减压病大鼠肺组织miR-16及miR-146 a表达变化
- Author:
Haitao WANG
;
Yiqun FANG
;
Xiaochen BAO
;
Pu YOU
;
Hengrong YUAN
;
Jun MA
;
Fangfang WANG
;
Hairong ZHANG
- Publication Type:Journal Article
- Keywords:
fast buoyancy ascent escape;
decompression sickness;
microRNA-16;
microRNA-146a
- From:Military Medical Sciences
2014;(7):485-487
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression levels of microRNA (miR)-16 and miR-146a in rat lungs of decompres-sion sickness (DCS) caused by fast buoyancy ascent escape or diving .Methods At 0.5 h after fast buoyancy ascent es-cape or diving, the pathological changes in rat lungs and expression levels of miR-16,and miR-146a were detected by re-verse transcription-quantitive polymerase chain reaction and compared with normal control group .Results The pathological characteristics of lungs in two DCS groups were tissue damage .At 0.5 h after DCS caused by fast buoyancy ascent escape , the lung tissue expression levels of miR-16 and miR-146a did not significantly change compared with normal control and diving DCS groups ,but the rat lung tissue expression level of miR-146 a in diving DCS group was obviously increased , com-pared with normal control group .Conclusion miR-146a may play a role in post-transcriptional regulation in the process of diving DCS .
