Protective effects of different doses of hydrogen-rich water on radiation injury in mice
10.3760/cma.j.issn.0254-5098.2014.08.005
- VernacularTitle:不同剂量富氢水对小鼠辐射损伤保护作用的研究
- Author:
Xiujun QIN
;
Jingjing YIN
;
Wenli XU
;
Hui YUAN
;
Jinping WEI
;
Jianguo LI
;
Quan AN
- Publication Type:Journal Article
- Keywords:
Hydrogen-rich water;
Gamma rays;
ICR mice;
Radiation injury
- From:
Chinese Journal of Radiological Medicine and Protection
2014;34(8):578-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effects of different doses of hydrogen-rich water on radiation injury in mice,so as to provide scientific basis for the application of hydrogen-rich water.Methods The ICR mice were randomly divided into control group,irradiation group,amifostine group and hydrogen-rich water of low,medium and high dose groups.The 30 days survival rate,body weight,hematology parameters,serum biochemical parameters,organ weight and coefficient,bone marrow micronucleus rate,bone marrow nucleated cell count were observed after total body irradiation with 9.0 Gy gamma rays.Results After 30 d of irradiation,the hydrogen-rich water showed obvious protective effect on the survival rate and body weight in a dose dependent manner so that the survival was significantly higher than that of irradiation group (t =-2.67,P ＜ 0.05).The biochemical index,such as TP,ALB and CRE in the low dose group,TP,ALB,TBIL and CRE in the medium dose group,and TP,ALB,GLU,TBIL,BUN,GRE and UA in the high dose group also indicated the protective effects of hydrogen-rich water (t =-2.04--4.11,P ＜ 0.05).But the protective effect of hydrogen-rich water was not observed in hematology,organ weight and coefficient,and bone marrow micronucleus induction.Conclusions The hydrogen-rich water has anti-radiation effect,which may depend on the dose of hydrogen.
