The applications of chromatin immunoprecipitation in the study on the downstream target genes of androgen receptor in prostate cancer cells
10.3760/cma.j.issn.1009-9158.2014.09.009
- VernacularTitle:染色质免疫共沉淀技术在前列腺癌细胞雄激素受体下游靶基因研究中的应用
- Author:
Siqi XU
;
Zhihua TAO
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Receptors,androgen;
Chromatin immunoprecipitation;
Gene expression regulation
- From:
Chinese Journal of Laboratory Medicine
2014;(9):673-677
- CountryChina
- Language:Chinese
-
Abstract:
Prostate cancer is one of the most common malignant tumor of male population in the West.Via binding to androgen response element in the genome and interacting with co-regulators,androgen receptor can participate in the development of prostate cancer and the convertion from androgen dependent prostate cancer to androgen independent prostate cancer.Chromatin immunoprecipitation ,coupled with PCR , chip,and high-throughput sequencing ,makes a huge progress in the study on the downstream target genes of androgen receptor and provide a new way to understand the molecular mechanisms of castration -resistant prostate cancer.
