Advances in pathogenesis of chronic idiopathic thrombocytopenic purpura
10.3760/cma.j.issn.1673-4408.2014.05.023
- VernacularTitle:慢性特发性血小板减少性紫癜发病机制研究进展
- Author:
Shanshan LI
;
Hui JIANG
- Publication Type:Journal Article
- Keywords:
Chronic idiopathic thrombocytopenic purpura;
Gene polymorphism;
Gene expression;
Epi-genetic
- From:
International Journal of Pediatrics
2014;(5):534-537
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic thrombocytopenic purpura (ITP),as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al.
