Clinical application of microRNA in gastric cancer
10.3760/cma.j.issn.1009-9158.2014.09.004
- VernacularTitle:microRNA 在胃癌中的临床应用
- Author:
Guangbin QIU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
microRNAs;
Biological markers;
Prognosis
- From:
Chinese Journal of Laboratory Medicine
2014;(9):653-656
- CountryChina
- Language:Chinese
-
Abstract:
microRNAs ( miRNAs) are a class of endogenous noncoding small molecular RNAs , which regulate target gene expression at the post-transcriptional level and play vital roles in cell development , proliferation, differentiation, tumorigenesis and other biological behavior.Changes in miRNA expression profiles have been observed in gastric cancer in recent studies.Further studies demonstrated that miRNAs were closely related to the carcinogenesis , development and metastasis of gastric cancer , which suggested miRNAs have broad prospective application in diagnosis and therapy of gastric carcinoma as biomarkers and therapeutic targets.