Oxidative stress of mitochondrial injury mechanism and targeted antioxidant in sepsis
10.3760/cma.j.issn.1673-4408.2014.05.002
- VernacularTitle:脓毒症线粒体损伤的氧化应激机制及靶向抗氧化剂的研究
- Author:
Min LAI
;
Shuangjie LI
- Publication Type:Journal Article
- Keywords:
Sepsis;
Oxidative stress;
Mitochondria;
Antioxidant
- From:
International Journal of Pediatrics
2014;(5):458-461
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria is an important part of cell oxidation, but oxidative stress in sepsis as end product of inflammation will cause changes of mitochondria, leading to organ damage. In general, antioxidant defense system fights oxidative stress through the interaction and prevents mitochondrial injury. Oxidative stress plays a important role in organ dysfunction. Studies have found that the targeted therapies for mitochondrial antioxidants may be a new strategy of multiple organ failure caused by sepsis. This review aims to summarize researches on oxidative stress of mitochondrial injury mechanism and targeted antioxidants in sepsis .
