Environmental endocrine disruptors and kisspeptin system
10.3760/cma.j.issn.1673-4408.2014.05.012
- VernacularTitle:环境内分泌干扰物与kisspeptin系统
- Author:
Ying ZHANG
;
Ruimin CHEN
- Publication Type:Journal Article
- Keywords:
Environmental endocrine disruptors;
Kisspeptin system
- From:
International Journal of Pediatrics
2014;(5):493-495
- CountryChina
- Language:Chinese
-
Abstract:
Environmental endocrine disruptors have garnered considerable attention in recent years be-cause of their endocrine disruption on sex development disorders. Kisspeptin system might be a novel target for endocrine disruption at the hypothalamic-pituitary-gonad axis. Environmental endocrine disruptors′estrogenic properties make them capable of interacting with the kisspeptin system,and then confer lifelong consequences in-cluding altered pubertal timing, infertility, and metabolic disorders. To date, three compounds have been well studied for their capacity to interfere with kisspeptin signaling pathways:BPA,PCB mixtures,and the phytoestro-gen GEN.
