Inhibitory Effect of Polypeptide P161 Combined with Cisplatin on Proliferation of Multiple Cancer Cells

VernacularTitle:多肽 P161联合顺铂对多种肿瘤细胞增殖的抑制作用
Author: Mengyi ZHANG ; Heng ZHENG ; Ying CHEN ; Jianhua CHEN
Publication Type:Journal Article
Keywords: Cisplatin; Polypeptide; Anticancer
From: Herald of Medicine 2014;(10):1288-1290
CountryChina
Language:Chinese
Abstract: Objective In vitro detection of anti-proliferative effects of P161 combined with cisplatin ( DDP) on multiple cancer cells. Methods Growth inhibition rates of HepG2, HT29, IE8, Panc-1 and MA-782 treated by different concentrations of DDP,P161 and P161 combined with DDP were determined by MTT assay. Results DDP and P161 dose-dependently inhibited proliferation of multiple tumor cells. A synergistic effect was found in DDP combined with P161 and there was a significant difference in the effect between DDP combined with P161 and DDP alone (P<0. 05). DDP dose could be decreased to reach the same inhibitory effect. In the same concentration gradient of DDP combined with P161,the inhibition rate of Panc-1 was low and that of MA-782 was high. Conclusion P161 can increase the sensitivity of tumor cells to DDP. The combination of P161 and DDP can reduce the effective therapeutic concentration of DDP.