Inhibitory Effect of Polypeptide P161 Combined with Cisplatin on Proliferation of Multiple Cancer Cells
10.3870/yydb.2014.10.008
- VernacularTitle:多肽 P161联合顺铂对多种肿瘤细胞增殖的抑制作用
- Author:
Mengyi ZHANG
;
Heng ZHENG
;
Ying CHEN
;
Jianhua CHEN
- Publication Type:Journal Article
- Keywords:
Cisplatin;
Polypeptide;
Anticancer
- From:
Herald of Medicine
2014;(10):1288-1290
- CountryChina
- Language:Chinese
-
Abstract:
Objective In vitro detection of anti-proliferative effects of P161 combined with cisplatin ( DDP) on multiple cancer cells. Methods Growth inhibition rates of HepG2, HT29, IE8, Panc-1 and MA-782 treated by different concentrations of DDP,P161 and P161 combined with DDP were determined by MTT assay. Results DDP and P161 dose-dependently inhibited proliferation of multiple tumor cells. A synergistic effect was found in DDP combined with P161 and there was a significant difference in the effect between DDP combined with P161 and DDP alone (P<0. 05). DDP dose could be decreased to reach the same inhibitory effect. In the same concentration gradient of DDP combined with P161,the inhibition rate of Panc-1 was low and that of MA-782 was high. Conclusion P161 can increase the sensitivity of tumor cells to DDP. The combination of P161 and DDP can reduce the effective therapeutic concentration of DDP.