Effect of Ionic Strength on Stability of Methotrexate-loaded Dendrimer Nanoparticles
10.3870/yydb.2014.10.030
- VernacularTitle:离子强度对甲氨蝶呤-树枝状大分子纳米粒稳定性的影响
- Author:
Yanna ZHAO
;
Li YANG
;
Chunying HAO
;
Yanhong LI
;
Xiangtao WANG
;
Yifei GUO
- Publication Type:Journal Article
- Keywords:
Methotrexate;
Ionic strength;
Size;
Nanoparticles;
Stability
- From:
Herald of Medicine
2014;(10):1365-1369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of ionic strength on the stability of the methotrexate-loaded dendrimer nanoparticles. Methods The influences of different ions (Na+,Cl-) and different concentrations of sodium chloride on the stability of the nanoparticles were studied. The particle size was measured by dynamic light scattering(DLS) and drug-loading content was determined by high-performance liquid chromatography (HPLC) in order to evaluate the stability. Results The Cl- was finally verified to play an important role in stabilizing the nanoparticles and the effective concentration of the sodium chloride was recommended to be below 1. 80% . Conclusion The recommended concentration (less than 1. 80% ) of the sodium chloride significantly improves the stability of the nanoparticles and benefits for long term storage.
