Protein kinases and neurodegenerative diseases
10.3867/j.issn.1000-3002.2014.05.011
- VernacularTitle:蛋白激酶与神经变性疾病
- Author:
Shengqian YANG
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
protein kinases;
neurodegenerative diseases;
Alzheimer disease;
Parkinson disease;
Huntington disease;
protein kinase inhibitors
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(5):748-757
- CountryChina
- Language:Chinese
-
Abstract:
Neurodegenerative diseases are complex nervous system disorders as a result of myelin damage,synapses loss and/ or neuron loss. The pathogenesis of these diseases is still not completely clear. Protein kinases play an important role in both normal nerve cells and neurodegenerative disorders. lnhibitors of protein kinases can effectively regulate the physiological function of nerve cells and prevent the development and progression of the disease. This article reviews protein kinases and their inhibitors involved in Alzheimer disease,Parkinson disease,Huntington disease and other neurodegenerative diseases.
