Progress in reguIation of phosphoIipase D mediated by Wnt/β-catenin and NF-κB signaIing pathways and its reIationships with tumorigenesis
10.3867/j.issn.1000-3002.2014.05.015
- VernacularTitle:Wnt／β连环素和NF-κB信号通路对磷脂酶D的调控作用及其与肿瘤关系的研究进展
- Author:
Xinghui HONG
;
Jinling HUANG
- Publication Type:Journal Article
- Keywords:
Wnt;
β-catenin;
NF-κB;
signaling pathway;
phospholipase D;
tumor
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(5):779-783
- CountryChina
- Language:Chinese
-
Abstract:
Over the last few years,elevated phospholipase D(PLD)expression and activity found to be mediated by Wnt/ β-catenin and NF-κB signaling axis sharing the same downstream genes have been involved in tumorigenesis,controlling cancer cell invasion and metastasis. New studies have revealed that Wnt signaling/ NF-κB signaling can induce PLD upregulation and increased enzymatic activ-ity. PLD/ PLD-generated phosphatidic acid( PA),as a critical regulator,might positively modulate β-catenin-dependent T-cell factor and NF-κB transcriptional activity via a targeted motif and a positive feed-back loop to reinforce pathway output including cyclin D1 ,c-myc,survivin,vascular endothelial growth factor and cyclooxygenase-2,while PLD/ PA inhibitors can reverse all the effect mentioned above and achieve significantly better anticancer effects. The PLD/ PA signaling pathway can be a novel therapeutic target for the treatment of cancer.
