Brief overview of transIationaI toxicoIogy
10.3867/j.issn.1000-3002.2014.05.019
- VernacularTitle:转化毒理学研究概述
- Author:
Yue LLU
;
Dan HU
;
Xing FAN
;
Chunqi WU
;
Quanjun WANG
;
Rigao DLNG
- Publication Type:Journal Article
- Keywords:
translational toxicology;
biological markers;
drug evaluation
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(5):801-805
- CountryChina
- Language:Chinese
-
Abstract:
As an integral part of translational medicine,translational toxicology is intended to apply the results of toxicological studies to the prevention of diseases and the harmful effects on organisms. As far as drug safety evaluation is concerned,translational work is focused on developing more sensitive and specific translational safety biomarkers. Previous research focused on indicators of the liver and kidney,cardiovascular damage in the early stage,and detection of early-stage cancer. MicroRNA is hot sphere of research and considered a potential biomarker. Translational toxicology requires multi-discipli-nary and multi-agency communication and cooperation. The approach adopted by the Predictive Safety Testing Consortium is relatively perfect and is worth learnikng from.
