Progress in drug transporters in hepatocytes
10.3867/j.issn.1000-3002.2014.05.020
- VernacularTitle:肝细胞药物转运体研究进展
- Author:
Rong ZHU
;
Yueming MA
- Publication Type:Journal Article
- Keywords:
hepatocytes;
drug;
transporters
- From:
Chinese Journal of Pharmacology and Toxicology
2014;(5):806-812
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic drug transporters(HDTs),including uptake transporters and efflux transporters, play an important role in drug distribution and elimination in the liver. The influx HDTs include organic anion transporters,organic cation transporters,organic anion transporter polypeptides and Na+-tauro-cholate cotransporting polypeptide. The efflux HDTs include multidrug resistance proteins,multidrug resistance-associated proteins,breast cancer resistance protein and bile salt export pumps. Major research methods involve gene knock-out animals,isolated perfused livers,liver slices,primary hepato-cytes and transfection cells. They have been used in study of drug distribution,drug-drug interaction and drug toxicity.
