Research progress on the role of autophagy in cardiovascular diseases
10.3969/j.issn.1001-1978.2014.10.004
- VernacularTitle:自噬在心血管疾病中的作用研究进展
- Author:
Chao LIN
;
Zhaoguo LIU
;
Xing QIAN
;
Bin XU
;
Dongqiao BAO
;
Yu LI
;
Huimin BIAN
- Publication Type:Journal Article
- Keywords:
autophagy;
physiological function;
angiogenesis;
cardiovascular diseases;
molecular mechanisms;
therapy strate-gies
- From:
Chinese Pharmacological Bulletin
2014;(10):1347-1349
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a common phenomenon which widely ex-ists in eukaryotic cells. Researches have shown that autophagy plays a critical role in maintaining cellular hemostasis, cell com-ponents update and keeping a normal physiological state. In re-cent years, the study has found that autophagy is closely related to the growth, the development of cardiovascular diseases and tumors. Further studies show that in different pathological condi-tions, autophagy could both promote angiogenesis and inhibit the formation of blood vessels. Therefore, it is particularly critical to elucidate the mechanisms of autophagy in the regulation of angio-genesis in different pathological conditions. The role of autophagy in cardiovascular diseases especially in the regulation of angio-genesis is discussed in this paper. Besides, the paper also in-cludes the discussion about the mechanisms of autophagy in the regulation angiogenesis, which may provide references for follow-up research and clinical treatment.
