Angiotensin Ⅱ and receptors in rheumatoid arthritis
10.3969/j.issn.1001-1978.2014.10.006
- VernacularTitle:血管紧张素Ⅱ及其受体与类风湿关节炎
- Author:
Di WANG
;
Shanshan HU
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
angiotensin Ⅱ;
type 1 receptor;
type 2 receptor;
rheumatoid arthritis;
immune and inflammation;
type receptor blocker
- From:
Chinese Pharmacological Bulletin
2014;(10):1353-1356
- CountryChina
- Language:Chinese
-
Abstract:
Angiotensin Ⅱ and type 1 receptor ( AT1R) are ab-solutely therapeutic targets in the hypertension and cardiovascular disease, and angiotensin Ⅱ gets involved in monocytes chemo-taxis and migration, T lymphocytes activation and proliferation, Th1 and Th17 immune function, and synoviocytes apoptosis inhi-bition in patients with rheumatoid arthritis ( RA) through binding to AT1R in the autocrine and/or paracarine manner. Drugs that limit angiotensin Ⅱ production by angiotensin converting enzyme inhibitors ( ACEIs) or blockade of angiotensin Ⅱ-AT1R action by AT1R blocker ameliorate immune and inflammation responses in RA patients. Additionally, angiotensin Ⅱ type 2 receptor (AT2R) expression increases in RA and experimental model, and activation of AT2R exerts a therapeutic effect on adjuvant-in-duced arthritis. AngiotensinⅡand its receptors in RA and auto-immune diseases are retrospectively reviewed in this paper.
