Advances of serum antibodies in myasthenia gravis
10.3760/cma.j.issn.1009-9158.2014.08.006
- VernacularTitle:重症肌无力血清抗体的研究进展
- Author:
Jie SONG
;
Ming GUAN
;
Jiahong LU
;
Chongbo ZHAO
- Publication Type:Journal Article
- Keywords:
Myasthenia gravis;
Autoantibodies;
Immunoassay
- From:
Chinese Journal of Laboratory Medicine
2014;37(8):577-581
- CountryChina
- Language:Chinese
-
Abstract:
Myasthenia gravis (MG) is an immune-mediated disorder of the neuromuscular junction that is characterized by fluctuating muscle weakness.Acetylcholine receptor antibody (AchR-Ab) is the first MG specific antibody being elucidated,however,the discovery of many other MG specific or related antibodies enriches its immunopathogenesis greatly.The detection of antibodies is very important for the diagnosis and classification of MG.It can be used to guide the clinical management and evaluate the response to treatment as well.With the development of laboratory medicine,the methods of antibody detection are also being optimized.In this paper,we will review the serum antibodies closely associated with MG and their mechanisms,detection methods and clinical significance.
