The curative effect analysis of oralYiyuan-Guchangdecoctionand enema retention of Yuyangyein treating chronic ulcerative colitis
10.3760/cma.j.issn.1673-4246.2014.10.005
- VernacularTitle:益元固肠汤口服联合愈疡液灌肠治疗慢性溃疡性结肠炎疗效分析
- Author:
Shaohua YANG
- Publication Type:Journal Article
- Keywords:
Yiyuan-Guchang decoction;
Yuyangye;
Ulcerative colitis;
Curative effect analysis
- From:
International Journal of Traditional Chinese Medicine
2014;(10):879-882
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the efficacy of oralYiyuan-Guchangdecoction and enema retention ofYuyangye in treating chronic ulcerative colitis(CUC).Methods 70 patients of CUC were randomly divided into two groups: a control group of 34 patients, treated by mesalazine(etiasa) orally, 1g/twice daily; and a test group of 36 patients, treated byYuyangyedecoction for oral administration andYuyangyeenema retention. The treatment course of both groups was 8 weeks. The curative effect, clinical symptoms, endoscopic sign and pathology, and ESR, CRP, IL-8, and IL-13 after one course of treatment, were analyzed statistically.Results The total effect of the test group and the control group was 94.44%(34/36) and 64.71%(22/34), and the difference was significant statistically(Z=-4.207,P<0.05). The effects of test group were superior than the control group in terms of the clinical symptoms, endoscopic sign, and histopathology(P<0.05). The ESR, CRP, IL-8, IL-13 of the test group were(13.5±3.3)mm/h,(8.26±1.54)mg/L,(0.85±0.17)ng/ml,(37.18± 14.58)pg/ml before the treament, and(7.0±2.4)mm/h, (3.56±1.03)mg/L,(0.38±0.08)ng/ml, (76.33± 23.74)pg/ml after the treatment; The ESR、CRP、IL-8、IL-13 of control group were(14.5±4.8)mm/h, (8.41 ±1.36)mg/L,(0.86±0.15)ng/ml,(40.46±14.47)pg/ml before the treatment and(7.5±3.5)mm/h,(3.63± 1.10)mg/L,(0.36±0.07)ng/ml,(55.84±17.52)pg/ml after the treatment. ESR, CRP and IL-8 of both groups decreased significantly(P<0.05), while IL-13 significantly increased(P<0.05). ESR, CRP, IL-8 had no obvious statistical significance(P>0.05)between the two groups, while IL-13 of the test group was superior than the control group(P<0.05).Conclusion The therapeutic effect of oralYiyuan-Guchangdecoction and Yuyangyeenema retention is good in treating chronic ulcerative colitis.
