The expression and significance of ERα,ERβ,PR,and Bcl-2 of endometrial polyps
10.3760/cma.j.issn.1008-6706.2014.18.025
- VernacularTitle:雌激素受体、孕激素受体及细胞凋亡调控因子在子宫内膜息肉组织中的表达及意义
- Author:
Hongmin QI
- Publication Type:Journal Article
- Keywords:
Polyps;
Endometrium;
Estrogen receptor;
Progesterone receptor;
Bcl-2
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(18):2781-2782
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of ERα (estrogen receptorα),ERβ(estrogen receptorβ),PR,and Bcl-2 of endometrial polyps.Methods 50 cases of endometrial polyp patients were studied.And 45 cases of endometrial normal subjects were selected as the control group.The enzyme-linked immunosorbent assay was used to detected the FSH,LH,E2,P,T and PRL six levels of the two groups.And endometrial ERα two groups of patients,ERβ,PR and Bcl-2 expression was studied.Results The FSH,LH,E2,P,T and PRL six levels of the two groups were no significant difference(P ＞0.05).Polyps in patients with proliferative phase of ERα,ERβ expression levels of the normal group had no significant difference (P ＞ 0.05),the expression level of PR(0.47 ± 0.02) point was significantly lower than that of the normal group(0.53 ± 0.02) point (t =10.383,P =0.000),Bcl-2 expression levels(0.53 ± 0.04) point was significantly higher than that of the normal group (0.49 ± 0.02) point (t =4.322,P =0.000).Polyps in patients with secretory phase of ERα,Bcl-2 expression levels (0.46 ± 0.07;0.43 ±0.04)point were significantly higher than that of the normal group (0.37 ± 0.05 ;0.39 ± 0.03) point (t =5.007,P =0.000; t =3.834,P =0.000),the expression level of PR (0.42 ± 0.02) point was significantly lower than that of the normal group (0.46 ± 0.01)point(t =8.486,P =0.000),there was no significant difference in expression levels between the two groups ERβ(P ＞0.05).Between the two groups displayed,ERα,PR proliferative phase of the normal group and the polyp group,the expression levels of Bcl-2 were significantly higher than that of the secretory phase (P ＜ 0.05).Conclusion The increase of the ERα,Bcl-2 expression levels,and the reduction of the level of PR expression in patients with endometrial polyps are closely related.
