Effects of β-aescine sodium plus oxiracetam on plasma homocysteine and MCP-1 protein in patients with acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2014.18.023
- VernacularTitle:β-七叶皂苷钠联合奥拉西坦对急性脑梗死患者血浆同型半胱氨酸和单核细胞趋化因子-1的影响
- Author:
Qiang WANG
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Oxiracetam;
β-aescine sodium;
Homocysteine;
Monocyte chemotactic factor
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;21(18):2776-2778
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of β-aescine sodium plus oxiracetam on plasma homocysteine (Hcy) and monocyte chemotactic factor(MCP-1) protein in patients with acute cerebral infarction.Methods 117 patients with acute cerebral infarction were randomly divided into the two groups,the observation group (n =60 cases) and the control group (n =57 cases).The patients in the control group were treated with the conventional treatment,while the patients in the observation group were treated with joint treatment ofβ-aescine sodium plus oxiracetam.They were treated for 14 days.Plasma Hcy and MCP-1 were detected.Results The total efficicies were 95.0％ in the observation group and 84.5％ in the control group.There was a significant difference between two groups (x2 =5.801,P ＜0.05).Plasma Hcy and MCP-1 were decreased after treatment (t =9.551,4.296,2.001,21.070,P ＜ 0.05,P ＜0.01).Plasma Hcy and MCP-1 in the observation group were lower than these in the control group (t =4.997,25.276,all P ＜ 0.05).Conclusion β-aescine sodium plus oxiracetam can decrease plasma Hcy and MCP-1 in patients with acute cerebral infarction.
