Role of AT1R-associated microRNAs in thyrotoxic heart desease
10.3760/cma.j.issn.1000-6699.2014.09.018
- VernacularTitle:与血管紧张素Ⅱ1型受体相关的微小RNA在甲状腺功能亢进性心脏病中的作用
- Author:
Huimin LI
;
Yunfei LIAO
;
Lulu CHEN
- Publication Type:Journal Article
- Keywords:
microRNA;
Renin-angiotensin system;
Angiotensin Ⅱ receptor 1;
Thyrotoxic heart disease
- From:
Chinese Journal of Endocrinology and Metabolism
2014;30(9):797-799
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are small endogenous non-coding RNA molecules.They regulate negatively the expression of target genes at post-transcriptional stages by means of affecting the stability of target mRNA or interfering with the transcriptional process.Recently,there is evidence demonstrating that miRNAs play important roles in the gene expressions of thyrotoxic heart diseases.Elevated levels of thyroid hormones profoundly influence the cardiovascular system through the renin-angiotensin system (RAS).As a principal active component of RAS,angiotensin Ⅱ receptor 1 (AT1 R) interacts with miRNAs in promoting or extenuating the progress of thyrotoxic heart disease.In this article,the roles of AT1R-associated miRNAs,miR-21,miR-155,miR-208a/b,and miR-499 in thyrotoxic heart disease were reviewed.
