Determination of Lurasidone Hydrochloride Tablets by HPLC
- VernacularTitle:HPLC法测定盐酸鲁拉西酮片的含量
- Author:
Cuiyan LIU
;
Qingjuan LI
;
Junhong FAN
;
Xiaoxue BAI
;
Manman WANG
;
Yanhua RONG
- Publication Type:Journal Article
- Keywords:
Lurasidone hydrochloride tablets;
Determination;
HPLC
- From:
China Pharmacist
2014;(9):1483-1485
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the content of self-manufactured and imported lurasidone hydrochloride tablets in order to e-valuate their internal qualities. Methods:The determination of lurasidone hydrochloride tablets was performed by HPLC. The HPLC system consisted of a Waters C8 column (250 mm × 4. 6 mm, 3. 5 μm) and the mobile phase of 0. 05 mol·L-1 phosphate buffer solu-tion (pH 3. 0)-acetonitrile(60∶40), the detection wavelength was 230 nm, the flow rate was 1. 2 ml·min-1 and the column tempera-ture was 40℃, and the injection volume was 20μl. Results:The linear range of lurasidone hydrochloride was 0. 100 8-0. 806 4 mg· ml-1(r=0. 999 5). The average recovery was 99. 95% with RSD of 0. 31%(n=9). Conclusion:The method is simple, rapid, ac-curate, and reliable. The method can determine lurasidone hydrochloride tablets satisfactorily. According to the results, there are few differences among the self-manufactured and imported lurasidone hydrochloride tablets.
