Optimization of Ethanol Extraction Technology for Xiaoluo Granules by Orthogonal Experiment
- VernacularTitle:正交试验设计优化消瘰颗粒剂醇提取工艺
- Author:
Yan WANG
;
Weimin CHEN
;
Yan HE
;
Jing DU
;
Yinghua FU
- Publication Type:Journal Article
- Keywords:
Xiaoluo granules;
Optimization of ethanol extraction technology;
Orthogonal experiment;
Baicalin
- From:
China Pharmacist
2014;(9):1486-1488
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the ethanol extraction technology for Xiaoluo granules. Methods:The extraction technology for the ethanol dissolvable ingredients in 10 kinds of medicinal materials was optimized by orthogonal experiment. The weighted sum of ba-icalin content and the dry extract rate as the index, 4 influencing factors with 3 levels each were optimized by L9 (34 ) orthogonal table. Results:The optimal ethanol extraction conditions were as follows:the medicinal material was soaked by 10-fold 50% ethanol solution for 45min, and then extracted by heating reflux for 3 times with 1. 5h each time. Conclusion: The method can effectively extract the ethanol dissolvable ingredients in 10 kinds of medicinal materials, which can be used as the ethanol extraction technology for Xiaoluo granules.
